Thrombophilia Panel Test

Thrombophilia is a broad medical term describing a multifactorial condition in which the blood has an increased tendency to clot and is considered hypercoagulable.

What is a thrombophilia panel?

A thrombophilia panel test is a test that determines whether genes that regulate blood clotting are damaged (mutated).

Due to clotting;

• Thromboembolism, Vascular Blockage,
• Clotting in the most important organs such as the heart, brain and lungs,
• Pregnancy Losses,
• Retarded development of the uterus,

There are also types of coagulation disorders that are not genetic but acquired. Such as antiphospholipid antibody syndrome.

In people who have Covid 19 disease; It has been observed that clotting is triggered if there is a problem with the genes belonging to the thrombophilia panel.

What does a thrombophilia test do?

Thrombophilia panel blood clotting gene disorder, which is among the pre-pregnancy tests, is very important. For this reason, it is recommended that people start blood thinner treatment against this genetic disorder. The dose should be determined by the attending physician.

It is important for individuals to have this information in order to prevent blood clots in the brain, lungs and heart at a later age, as well as during pregnancy or gestation.

Who is tested for thrombophilia?

• Vascular occlusion at a young age,
• Those with a family history of stroke, heart disease, etc. due to vascular occlusion,
• Those with pre-eclampsia or difficulty in developing in the early months of pregnancy within 1 (~) 3 months,
• History of miscarriage,
• People with a history of stillbirth should have a thrombophilia panel test.

How is the thrombophilia panel test performed?

For the thrombophilia panel test, it will be sufficient to take 1 tube of blood from the arm (ETDA tube with purple cap). The tube taken and the method used may vary according to the institution performing the test.

What does 3's 5's 12's mean?

Although it is recommended that the thrombophilia panel genes be screened in 12s, genes can also be examined individually or in certain groups in line with the consultancy and opinions of medical geneticists, gynecologists, hemotologists and other unit specialists.

Which genes are included in the thrombophilia panel?

• Factor II-Prothrombin G20210A
• MTHFR C677T
• Factor V Leiden G1691A
• MTHFR A1298C
• PAMI 4G/5G
• Factor XIII
• Factor V 1299
• Factor V A5279G
• Factor V Cambridge G1091C
• MTRR A66G
• MTR A2756G
• Beta Fibrinogen G-455A

Thrombophilia Test Price

For Thrombophilia Panel Test Price information, you can get price information from WhatsApp line +90532 746 93 36+90312 217 32 26 for fixed line and by e-mail.

What does normal thrombophilia panel mean?

If the thrombophilia panel test result is "normal", it means that there is no problem with these genes, that is, they do not carry mutations. It means that there is no genetic problem affecting blood clotting. Additional tests may be requested based on the patient's complaints and family history.

How to recognize thrombophilia?

Whether thrombophilia (blood clotting) is genetic or not is determined by the thrombophilia panel test. If the test result is homozygous or heterozygous, it means that there is a genetic problem in blood clotting.

What does thrombophilia panel heterozygous and homozygous mean?

If the thrombophilia panel test result is "homozygous" or "heterozygous", it means that there is a problem in these genes, that is, they carry mutations.

Considering the mutated genes, the requesting doctor should start blood thinning medication or injection therapy for the patient. If the individual follows this treatment regularly throughout his/her life, before and during pregnancy, he/she will not have any problems with blood clotting.

Which department deals with thrombophilia?

In order to have a thrombophilia panel test and in line with the consultancy and opinions of medical geneticists, gynecologists, hemotologists and other unit specialists and patient complaints, the thrombophilia panel test can be checked in the genetic units of hospitals or genetic diagnosis centers in line with the patient's request.

What causes thrombophilia?

Factor II-Prothrombin G20210A, MTHFR C677T, Factor V Leiden G1691A, MTHFR A1298C, PAI 4G/5G, Factor XIII, Factor V 1299, Factor V A5279G, Factor V Cambridge G1091C, MTRR A66G, MTR A2756G, Beta Fibrinogen G-455AM genes cause thrombophilia. Mutations in these genes (homozygous, heterozygous) cause thrombophilia.

Does thrombophilia prevent pregnancy?

Mutations in important genes in the thrombophilia panel may prevent pregnancy from occurring or progressing. It must be checked before and during pregnancy. If the pregnancy does not occur or does not progress and the family history shows this picture, the thrombophilia panel test should be checked and the necessary treatment should be taken.

When is the blood clotting injection started?

According to the thrombophilia panel test, the mutated (homozygous, heterozygous) genes are determined and the dose of the blood thinner needle is determined and treatment is started, taking into account the number of genes and which genes have mutations.

What should people with blood clots pay attention to?

People with blood clotting problems should be under regular medical supervision as it may trigger other health problems (high blood pressure, miscarriage, inability to conceive, clots in organs, etc.). They should regularly use the blood thinning injection or medication that their doctor deems appropriate at the dose and time deemed appropriate.

Does blood thinner prevent clots?

If the blood thinner needle or medication determined according to the results of the thrombophilia panel test is used at the specified doses and times, it will prevent blood clots to a large extent.