Chromosome Analysis from Peripheral Blood

What is Peripheral Blood Chromosome Analysis (PK)?

Newly married couples or expectant mothers and fathers who want to have a baby should receive genetic counseling and have a chromosome analysis, also known as karyotype determination.

With Chromosome Analysis, structural or numerical disorders in the chromosomes of individuals are diagnosed and diagnosed. Chromosome analysis detects chromosomal abnormalities such as translocations, duplications and deletions.

If the chromosomal defects that may occur during fertilization of individuals who are translocation carriers are known by family members; The family is informed that in order for their children to be healthy, embryos should be selected by IVF, i.e. in vitro fertilization, instead of spontaneous pregnancy.

How is Peripheral Blood Chromosome Analysis Performed?

A blood sample is taken from individuals who come to Ankara Genetics in a green-capped lithium heparinized tube. This peripheral blood sample is cultured and then its karyotype is determined by examining the chromosomes of each cell with high-level analysis methods. People can learn the results of their tests within 10 (~) 15 days.

Who is Peripheral Blood Chromosome Analysis Performed?

• Newly married couples,
• For couples who want to have children,
• Those with a history of chromosomal analysis detected in the family pedigree,
• Individuals in consanguineous marriages,
• Individuals that the clinician is suspicious of,
• Individuals with short stature, blindness, developmental delay, gender anomaly, undefined genetic disorders detected after birth.

Cytogenetics

Cytogenetics is the branch of science that studies the numerical and structural status of chromosomes. There are 46 chromosomes (23 pairs) in humans. Two of these (X, Y) are sex chromosomes.

23 of the chromosomes come from the mother and 23 from the father. Of these chromosomes, 22 are autosomal chromosomes and 1 pair are sex chromosomes (X, Y genes related to reproduction).

Anomalies in these chromosomes have a major impact on development, growth and organ function. For example, a person with 47 chromosomes instead of 46 has Down syndrome and the associated changes in physical characteristics.

Chromosomes have a centromere and p and q arms. The short arm is called p and the long arm is called q. In peripheral blood chromosome analysis, each chromosome is evaluated by means of high-tech software and devices and accompanied by a team of experts, and a result report is given to you within 10 (~) 15 days.